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Case Study This is a 47 year old man who presents with a scaly nodule on the shoulder. Diagnosis Cystic (Inverted) Warty Dyskeratoma Discussion Warty dyskeratomas are relatively common epithelial lesions characterized by invaginated cup-shaped cyst with an extensive keratotic and parakeratotic plug. Characteristically there is suprabasilar acantholysis with papillary fronds and numerous acantholytic cells with dyskeratosis forming corp ronds and corp grains. This recent paper cited below describes several histological variants including tumors which may exhibit follicular differentiation. PCR analysis for HPV DNA was negative in all cases, distinguishing it from verruca vulgaris and cystic verruca. References Warty Dyskeratoma and other Acanthomas
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Last Updated November 10, 2002
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