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![](../photos/multicentric_reticulohistiocytosis_clin1a.jpg)
Image 1
![](../photos/multicentric_reticulohistiocytosis_clin2a.jpg)
Image 2
![](../photos/multicentric_reticulohistiocytosis_clin3a.jpg)
Image 3
![](../photos/multicentric_reticulohistiocytosis_clin4a.jpg)
Image 4
Image 5-Low power magnification showing diffuse replacement of the dermis by a cellular infiltrate, separated from the epidermis by a Grenz zone.
Image 2
Image 3-Higher power magnificatioin exhibiting histiocytic appearing cells with occasional giant cells.
Image 4
![](../photos/multicentric_reticulohistiocytosis1_6_p53.jpg)
Image 5-Diffuse nuclear positivity for p53.
Image 6-Diffuse immunopositivity for CD68
![](../photos/multicentric_reticulohistiocytosis1_7_cd1a.jpg)
Image 7-Immunohistochemical stains for CD1a, Cytokeratin, S100, and smooth muscle actin were negative. CD45 revealed focal positivity.
What is your diagnosis? |
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Case Study
This is a 56 year old woman who presents with an acute onset of multiple erythematous papules occurring on the proximal extremities, trunk, head, and neck.
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